The Open Targets team at our 10 year anniversary celebration in October 2024
Join our team!
Open Targets is based on the stunning Wellcome Genome Campus, home to some of the world's foremost institutes and organisations in genomics and computational biology. We work in dynamic teams at the interface of academic and pharma industry science on a crucial problem, how to be more successful in making drugs. Working with us, you will be exposed to new technologies and a dynamic set of scientists dedicated to translational research.
Our posts are usually in either one of our academic partners, The Wellcome Sanger Institute or EMBL-EBI and have terms and conditions associated with the employer.
Important note: applications may be reviewed on an ongoing basis and the advertised post(s) may be filled before the stated deadline.
Staff Scientist | Trynka group
Application closing date: 8 April 2025
Leverage CRISPR technologies to uncover how disease-associated genes regulate immune cell function. This role is for a 12 month fixed term contract.
You will coordinate and support the development and execution of experimental workflows of a collaborative project which aims to use CRISPR tools to link gene perturbations through transcriptional programmes to cell functions in primary immune cells, working closely with experts from academia and industry. Specifically, your focus will be in setting up CRISPR knock-out and activation protocols for perturbing CD8+ T cells and supporting parallel work in CD4+ cells.
IMMERSE brings together expertise from Open Targets industry partners and four research groups (Trynka, Vento, Speak, and Soskic) each focused on an immune cell type, with an ambitious goal to uncover transcriptional programmes underpinning key immune cell functions. For this, we are generating large-scale transcriptional profiles for hundreds of gene perturbations to ultimately uncover disease biology and inform drug target discovery. Specifically, in our group we focus on the T cell arm.