IDIC fine-mapping pipeline

IDIC is an Open Targets workflow for fine-mapping GWAS summary statistics at scale. It uses Nextflow for orchestration, containerized execution, Open Targets Gentropy-compatible data models, and pan-UK Biobank linkage disequilibrium resources.

Pipeline documentation

• Pipeline overview
  • Outputs
  • Data resolution
• Execution
  • Local execution
  • Nextflow profiles
  • Gentropy alternatives
  • Fine-mapping containers
  • Hailing Ducks LD validation
• Workflows
  • Locus breaker
  • Locus collection
  • Locus annotation
  • Fine-mapping
• QC and validation
  • Validation stages
  • Status record schema
  • Why the filtering key changes
  • Duplicate summary-statistics limitation
  • Triggering validation paths in stub tests
• Locus processing
  • Locus breaker
  • Locus collection
• Fine-mapping routes
  • Available methods
  • LD interface
• Hailing Ducks LD annotation benchmark
  • Decision
  • Environment and method
  • Results
  • Correctness findings
  • Operational safeguards
• Collector API
  • Command surface
  • Locus breaker
  • Canonical regions
  • Schema contracts
• Presentations
  • 13 August 2026 project update

Indices and tables

• Index

• Module Index

• Search Page